Institutional Repository
Thesis Issued 2026-09-09 EN

Bacterial Isolates Related to Water Pollution and Their Plasmids Implicating Drug Resistance Hazards

Author: Md. Atawar Rahman

Abstract

The ground and surface water obtained from various sources such as tap, tubewell, pond, river and sea were studied in three different seasons: summer, rainy and winter, for the evidence of fecal pollution. A total number of 690 samples were bacteriologically examined for the determination of total coliforms, fecal coliforms, total bacterial count and presence of Escherichia coli, fecal streptococcі, Salmonella typhimurium, Salmonella paratyphi, Shigella dysenteriae, Shigella flexneri and Shigella sonnei. The physico-chemical factors of water samples and their influence on water quality were analysed. The bacterial isolates of water were tested for their sensitivity to seven antibiotics, Ten selected isolates were further studied for plasmid determination. The level of pollution with MPN of total coliforms ranged from 0 to 2400, fecal coliforms 0 to 920 and total bacterial count (log10) 1.17 to 7.98 per 100 ml of water samples of different sources. The degree of pollution was the highest in river water and the lowest in tubewell water. The counts were significantly (P<0.05) different from each other except in tap and tubewell water. Results indicated that densities of fecal pollution in pond and river water were markedly influenced by seasonal variation (summer, rainy and winter) but such influence there was no of seasonin tubewell and tap water. Pollution was higher during summer and winter than rainy season, but the degree of contamination was remarkably high in river water during rainy season. Out of the total 690 samples examined, 58 per cent were found positive for fecal streptococci, 77 per cent E. coli, 35 per cent Sal. typhimurium, 30 per cent Sal. paratyphi and 101 per cent Shigella, of which 40 per cent were Shigella dysenteriae, 28 per cent Shigella flexneri and 30 per cent Shigella sonnei. The highest recovery of bacterial isolates was obtained in pond water and the lowest in tubewell water. The results depicted that the combined effect of physico-chemical properties of water on the growth and propagation of bacteria in summer, rainy and winter seasons were highly significant (P<0.01) in pond, river and sea water, except in sea water in winter. The impact of physicochemical factors on the growth of bacteria in the tap and tubewell water was very poor and insignificant (P>0.05). Antibiotic resistant of bacterial pattern enteric isolates obtained from water of domestic uses have revealed that the maximum 90.15 per cent isolates weve resistant to tetracycline, whereas the minimum 2.0 per cent isolates were resistant to spectinomycin. Among these isolates E. coli. possesed the highest and Shigella flexneri had the lowest drug resistant property. Out of the total E. coli isolates,6.74 per cent were found to be resistant to all of the antibiotics tested. Combination of antibiotics has been found to be more efficacious on bacterial isolates. The use of single antibiotic resulted in 83.95 to 112.67 per cent resistant bacterial isolates, but when used in double, triple or more combination, this resistance decreased even up to zero level. All of the strains, examined for the plasmid study, exhibited resistance to tetracycline and frequently possessed multiple antibiotic resistance properties. The data obtained from the study revealed that the tetracycline resistance property was encountered by four different river isolates representing different genera. This could be due to the presence of plasmid which appeared to confer resistance to 20 mcg/ml streptomycin as well as tetracycline. The fifth river isolate was found to be capable of transferring tetracycline resistance and/or resistance to 100 mcg/m1 streptomycin by conjugation in broth mixtures in vitro.